The New York Giants and New England Patriots meet in Week 6 on Thursday Night Football.

The storied history between the Giants and Patriots includes Big Blue’s iconic Super Bowl upsets after the 2007 and 2011 seasons. Tom Brady — amazingly, at age 42 — remains at quarterback for the Patriots, but Eli Manning has been benched by the Giants, replaced by promising rookie Daniel Jones.

Brady and head coach Bill Belichick have the Patriots at 5-0 as they pursue a seventh Lombardi Trophy as a tandem, and with the NFL’s top-ranked defense, they are massive favorites to remain undefeated against the rebuilding, short-handed Giants (2-3). Looking for a prediction? The Post’s Paul Schwartz is going with Patriots 34, Giants 9.

Here’s how to watch the action:

What time does the Giants-Patriots game start?

The game is on Thursday, October 10. The game starts (kickoff time) at 8:20 p.m. ET.

Where is the game?

The Patriots are the home team at Gillette Stadium in Foxborough, Massachusetts.

Which key Giants and Patriots players will miss the game due to injury?

Giants star running back Saquon Barkley (ankle) will miss his third straight game, and backup running back Wayne Gallman (concussion) is out as well. Sterling Shepard, the Giants’ top receiver, will miss the game due to his second concussion of the season, and starting tight end Evan Engram (knee) also has been ruled out.

The Patriots will be without wide receiver Phillip Dorsett (hamstring) and running back Rex Burkhead (foot). Top wideouts Julian Edelman (chest) and Josh Gordon (knee) are listed as questionable.

What channel is the game on and can I stream it?

Thursday Night Football will be televised on Fox and NFL Network.

With a valid cable login, you can stream the game on and the Fox Sports app. NFL Network subscribers can live stream via the NFL Network website or the Watch NFL Network app.

If you subscribe to fuboTV, you can access either stream.

The Giants-Patriots game also will be streamed on Amazon Prime Video; you can watch live with an active Prime membership.

Primetime regular season games are available to stream via Yahoo Sports on your smartphone or tablet.

What are the betting lines for the Giants-Patriots game?

The Patriots are favored by 17 points over the Giants. The Over/Under is 41.